I haven't used the W6v2s in my own vehicles, but in cars we used to set up with them, we usually used the Kicker 800.2 amplifier, which has been replaced by the newer Kicker 850.2.
I have one car using a single Orion 2125SX for an 8 speaker system, and in the other car I have three Orion 2250SX amplifiers for another 8 speaker system.