How are you gonna couple them to the cab of the truck? How are you planning on keeping them dry? This is 2 ?'s off the top of my head. In other words, YES there are disadvantages to putting subs in the bed of the truck. Although I have seen pictures of it being done. A dude in sunny Calif. had a 100,000 watt set up in the bed of his multi tilting s10. Said he was the hit of all the beach parties he went to. Dont figure. LOL